League of Legends requires administrative privileges to install and run correctly. There are several fixes for this problem which are described below.
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Check your Hard Drive for errors
Occasionally, these problems can be caused by a corrupt disk fragment. To check for corruption, run a Scandisk on the drive:
Reinstalling the game as an Administrator:
If all else fails you may need to re-install the game with administrative rights using this guide:
https://support.riotgames.com/hc/en-us/articles/202539040
Once you've uninstalled the game, right-click the installer and select "Run as Administrator."
Still having issues?
If none of the above points helped, please submit a ticket to Player Support. In order to help us resolve your issue quickly, please include the following information in your ticket: